EJMCR. 2017; 1(May 2017): 86-91

Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report

Authors: Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker.

ABSTRACT

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome manifests as a significant, medication-induced, adverse reaction with cutaneous, hematological and multi-organ involvement. Sero-negative autoimmune encephalitis is inflammation of the brain secondary to autoimmune processes in the absence of an identifiable autoantibody. Case presentation: We present a pediatric case of sero-negative autoimmune encephalitis who subsequently developed DRESS syndrome as a result of exposure to ceftriaxone, omeprazole or acyclovir. She did not respond to either high-dose steroids or intravenous immunoglobulins (IVIG). Plasmapheresis was successful in treating symptoms relevant to both DRESS and sero-negative autoimmune encephalitis. No side effects were encountered. Conclusion: To our knowledge, plasmapheresis has only been reported once to treat DRESS syndrome in a pediatric patient. Early recognition and treatment of this syndrome is paramount. We suggest that plasmapheresis is a relatively safe alternative treatment option for resistant cases especially within the context of other autoimmune conditions.

Keywords:
Plasmapharesis, DRESS syndrome, ceftriaxone, omeprazole, aciclovir, sero--negative autoimmune encephalitis, case report


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Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report


Authors
Amybel Belladonna Taylor
Department of Paediatric Neurology, Bristol Royal Hospital for Children, Bristol, UK
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May Lynn Yeap
Department of Paediatric Neurology, Bristol Royal Hospital for Children, Bristol, UK
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Peta Sharples
Department of Paediatric Neurology, Bristol Royal Hospital for Children, Bristol, UK
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Mohamed Osman Eltahir Babiker
Faculty of Medicine, University of Bristol, Bristol, UK.
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Correspondence to:
Amybel Belladonna Taylor. Amybel Belladonna Taylor, Faculty of Medicine, University of Bristol, Bristol, UK.; amybeltaylor@mac.com

Publication history
Received 15 Apr 2017
Accepted 10 May 2017

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Pubmed Style

Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker. Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. EJMCR. 2017; 1(May 2017): 86-91. doi:10.24911/ejmcr/1/21


Web Style

Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker. Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. http://www.ejmcr.com/?mno=264181 [Access: November 21, 2018]. doi:10.24911/ejmcr/1/21


AMA (American Medical Association) Style

Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker. Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. EJMCR. 2017; 1(May 2017): 86-91. doi:10.24911/ejmcr/1/21


Vancouver/ICMJE Style

Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker. Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. EJMCR. (2017), [cited November 21, 2018]; 1(May 2017): 86-91. doi:10.24911/ejmcr/1/21


Harvard Style

Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker (2017) Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. EJMCR, 1 (May 2017), 86-91. doi:10.24911/ejmcr/1/21


Turabian Style

Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker. 2017. Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. European Journal of Medical Case Reports, 1 (May 2017), 86-91. doi:10.24911/ejmcr/1/21


Chicago Style

Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker. "Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report." European Journal of Medical Case Reports 1 (2017), 86-91. doi:10.24911/ejmcr/1/21


MLA (The Modern Language Association) Style

Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker. "Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report." European Journal of Medical Case Reports 1.May 2017 (2017), 86-91. Print. doi:10.24911/ejmcr/1/21


APA (American Psychological Association) Style

Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker (2017) Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. European Journal of Medical Case Reports, 1 (May 2017), 86-91. doi:10.24911/ejmcr/1/21


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