Background: Mycosis fungoides (MF) is a rare type of non-Hodgkin’s lymphoma of T cells that primarily affects the skin. Radiation therapy is a cornerstone of therapy for all stages. Case Presentation: A 76-year-old man diagnosed in 2010 with MF in the patch/plaque phase (stage IB T2 N0 M0 B0) was treated with topical corticosteroids and successive sessions of photochemotherapy (psoralen and ultraviolet A) and phototherapy (narrowband ultraviolet B) with relative control of the lesional condition for 9 years. Due to the absence of clinical response and progression of the lesions, it was proposed for the treatment with radiotherapy. The patient underwent total skin electron beam therapy (TSEBT) (6 MeV electron/30/1 Gy per day/4 days per week). The patient showed marked improvement of the lesional condition with minimal toxicity. Remains in follow-up, with good control of the disease to date. Conclusion: MF is a challenging disorder from all perspectives. TSEBT in patients with extensive patches or plaques has an excellent response rate and rapid palliation.

Keywords: T-cell lymphoma cutaneous, mycosis fungoides, skin neoplasms, radiotherapy, total skin electron beam therapy, case report