Background: Intussusception in adults is distinct from pediatric intussusception in many aspects. In contrast to intussusceptions in children, a demonstrable etiology is found in 70%-95% of the cases in the adult population, and approximately 40% of them are caused by primary or secondary malignant neoplasms. But lymphomas, as a cause of lead point in adult intussusception, are extremely rare and only less than 50 cases have been reported in the literature. Case Presentation: We are reporting a 44-year-old male who presented with a right iliac fossa mass and clinical features of intussusception and who was operated upon. Per-operative findings were consistent with ileocecal intussusception and a radical right hemicolectomy was conducted. Histopathological examination revealed it as a case of Diffuse Large B Cell Lymphoma presenting as the lead point. This case is discussed because of the rarity of the disease and possible cure if diagnosed early and treated aggressively. Conclusion: Ileocolic intussusception is adults is usually caused by malignancy and mostly as adenocarcinoma. Non-Hodgkin lymphoma as a lead point is extremely rare and is usually a histologic surprise. However, a radical en mass resection without reduction is ideal in all forms of adult colocolic and ileocolic intussusception.

Keywords: Ileocolic, intussusception, diffuse large B cell lymphoma (DLBCL)