Background: Pemphigus vulgaris (PV) is a rare autoimmune chronic blistering skin disease of type II hypersensitivity reaction. Case Presentation: The authors present a case of a 42-year-old male with the chief complaint of crusted plaques on face, chest, and scalp for 3 months associated with itching. On investigation, direct immunofluorescence showed immunoglobulin G antibodies. The patient was prescribed antibiotics, anti-inflammatory agents etc., but they did not show any effect. So, the physicians opted for pulse therapy. Conclusion: PV is a rare chronic ulceration of the mucosa where crusted plaques and blisters are seen. This condition can be effectively resolved using glucocorticoids and immunosuppressant. If untreated, this may lead to the death of the patient.

Keywords: Case report, autoimmune, blistering, hypersensitivity, steroids, acanthosis