Background: Though tuberculosis strictures are the most common cause of acute intestinal obstruction, in rare patients, malignant strictures are found in the jejunum causing acute intestinal obstruction and biopsy of these strictures came out to be jejunal adenocarcinoma. Case Presentation: In this case series, we presented three cases of jejunal adenocarcinoma who presented in the emergency department with sign and symptoms of acute intestinal obstruction and peritonitis. All were operated and samples were sent for histopathology which shows jejunal adenocarcinoma in all three cases. Patients were sent to oncology department for adjuvant radiotherapy. Fortunately, all patients responded well to radiotherapy and post op follow up was satisfactory. Conclusion: Although a rare entity, the operating surgeon should keep a high suspicion for malignancy in cases of acute intestinal obstruction if strictures are found in jejunum and cancer directed surgery technique should be followed because this timely treatment is the best survival offer for the patient in otherwise aggressive disease.

Keywords: Case series, jejunum, small intestine, adenocarcinoma, obstruction, oncology.