Rheumatoid Arthritis Diagnostic Pitfalls: Dont Overlook Large Joint Efussion
Authors:
Perdana Aditya Rahman
, Michelle Anabel
, ms. Dyto Prasetya Buwana
, Farah Diyah Anjani
Abstract
Background Rheumatoid arthritis (RA) is a systemic autoimmune disease that commonly presents of inflammatory symmetric polyarthritis in small joints and may also have extra-articular involvement. Early diagnosis and treatment within the first 3 months are important to reduce progression and deformities. In some cases, large joint involvement may also present or initially present in RA, which may lead to lower suspicion of RA at the initial visit and results in delayed diagnosis. Case Presentation Here we present a case of female, 55 years old with knee joint pain and effusion, which initially thought to be osteoarthritis. The patient had inflammatory arthritis features including morning stiffness, pain worsened at rest, and arthritis also involving hands. Yet, the patient was confirmed as having rheumatoid arthritis based on clinical, serological, and radiological features. In the detailed evaluation of knee radiographic examination, bone erosions were identified at a second look. Conclusion Inflammatory arthritis involving large joints requires detailed history taking of other joint involvement, serologic evaluation and also thorough radiographic interpretation, thus diagnosis of rheumatoid arthritis involving large joint can be established properly.
Keywords: Knee joint, Joint Efussion, Joint Disease, Rheumatoid Arthritis, Osteoarthritis, Case Report
Pubmed Style
Perdana Aditya Rahman, Michelle Anabel, ms. Dyto Prasetya Buwana, Farah Diyah Anjani. Rheumatoid Arthritis Diagnostic Pitfalls: Dont Overlook Large Joint Efussion. EJMCR. 2026; 04 (April 2026): -. doi:10.24911/ejmcr.9-2417
Publication History
Received: December 09, 2025
Revised: February 17, 2026
Accepted: February 18, 2026
Published: April 04, 2026
Authors
Perdana Aditya Rahman
Rheumatology-Immunology Division, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Malang
ms. Dyto Prasetya Buwana
Brawijaya University, Faculty of Medicine
Farah Diyah Anjani
Brawijaya University, Faculty of Medicine